New publication from the Hanlon Lab:
Hanlon S. L., and R. S. Hawley, 2023 B chromosomes reveal a female meiotic drive suppression system in Drosophila melanogaster. Curr Biol. https://doi.org/10.1016/j.cub.2023.04.028
May 8, 2023
February 13, 2023
October 31, 2022
New head of the Department of Molecular and Cell Biology explains the complexities of the evolving field — and why well-trained scientists are in high demand. Read full article in UConn Today
September 15, 2022
Jelena Erceg is studying the role of parental genome folding during development which could support the development of personalized genome medicine for chromosome-based diseases.
August 16, 2022
Assistant Professor Jelena Erceg (Department of Molecular and Cell Biology, CLAS & Institute for Systems Genomics, joint appointment also with the Department of Genetics and Genome Sciences, UConn Health) has received a prestigious R35 Maximizing Investigator’s Research Award (MIRA) for Early Stage Investigators from the National Institute of Health (NIH) and National Institute of General Medical Sciences (NIGMS). This award will support research in the Erceg Lab on genome folding and regulation over the next 5 years.
The title of the funded project is “Genome Folding and Regulation in Diploid Multicellular Organisms”
About the research and why it is important
MIRA provides support for the research in an investigator’s laboratory that falls within the mission of NIGMS. The goal of MIRA is to increase the efficiency of NIGMS funding by providing investigators with greater stability and flexibility, thereby enhancing scientific productivity and the chances for important breakthroughs. The program will also help distribute funding more widely among the nation’s highly talented and promising investigators.
August 15, 2022
Fleck K, Raj R and Erceg J (2022), The 3D genome landscape: Diverse chromosomal interactions and their functional implications. Front. Cell Dev. Biol. 10:968145. doi: 10.3389/fcell.2022.968145
July 18, 2022
Venkata S.P. Patchigolla, Barbara G. Mellone, Enrichment of Non-B-Form DNA at D. melanogaster Centromeres, Genome Biology and Evolution, Volume 14, Issue 5, May 2022, evac054, https://doi.org/10.1093/gbe/evac054
October 6, 2020
Rachel O’Neill is among five UConn researchers awarded internal funding to support researchers who are using their expertise to find new solutions to address the Covid-10 pandemic The program will award up to $50,000 to recipients.
Dr. Rachel O’Neill was awarded $50,000, Rapid and Ultrasensitive SARS-CoV-2 Detection in Wastewater by Smartphone
Co-PIs: Maroun Sfeir, Pathology and Laboratory Medicine
March 24, 2020
Rachel J. O’Neill, Institute for Systems Genomics, Molecular & Cellular Biology, Genetics and Genome Sciences, College of Liberal Arts and Sciences to be inducted into the Connecticut Academy of Science and Engineering (CASE) for 2020.
According to CASE, election to the Academy is based on the applicant’s scientific and engineering distinction, achieved through significant contributions in the form of publications, patents, outstanding leadership, and other factors. Read full article in UConn Today
February 26, 2020
The Mellone Lab was featured in UConn Today – UConn cell biologist Barbara Mellone, her student Jason Palladino, and colleagues report in the cover article of the 10 February issue of Developmental Cell that they were able to make fake centromeres that fooled cells into rearranging their chromosomes.
Fluorescence images of mitotic cells with de novo centromeres from Drosophila melanogaster larval brains. The chromosomes are stained with DAPI (DNA, magenta) and CENP-C antibodies (kinetochore protein, green) and are shown within the outlines of fruit flies. (Courtesy of Barbara Mellone)
Read article in UConn Today
See cover story at Developmental Cell